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CMap Candidate Details

Structure:
CMap ID: C00418
Pert ID: BRD-K33852358
Compound Name: arofylline
Targets: PDE4A
MoA: phosphodiesterase inhibitor
SMILES: CCCn1c(=O)n(-c2ccc(Cl)cc2)c2[nH]cnc2c1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96771 BRD-K33852358 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120524 BRD-K33852358 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120561 BRD-K33852358 A549 0.125 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
120635 BRD-K33852358 HELA 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
120663 BRD-K33852358 HT29 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.4
120715 BRD-K33852358 JURKAT 3.33 uM 24 h 0.29 1.21 0.47 0.0 0.0 0.0
120824 BRD-K33852358 YAPC 0.04 uM 24 h 0.23 0.96 0.07 0.23 0.82 0.1
129006 BRD-K33852358 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129056 BRD-K33852358 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).