CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04194
Pert ID:	BRD-K90333595
Compound Name:	phentolamine
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C
MoA:	adrenergic receptor antagonist
SMILES:	Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4501	BRD-K90333595	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.58
5133	BRD-K90333595	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.91	0.29
37416	BRD-K90333595	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37757	BRD-K90333595	ASC	10 uM	24 h	0.23	0.94	0.06	0.25	0.88	0.19
37954	BRD-K90333595	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.95	0.41
38572	BRD-K90333595	NPC	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.07
38792	BRD-K90333595	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39018	BRD-K90333595	SKB	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.51
90973	BRD-K90333595	HUH7	12 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
127347	BRD-K90333595	A375	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127421	BRD-K90333595	HA1E	10 uM	24 h	0.0	0.0	0.0	0.23	0.81	0.09
127461	BRD-K90333595	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127510	BRD-K90333595	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127602	BRD-K90333595	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127643	BRD-K90333595	THP1	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127680	BRD-K90333595	YAPC	1.11 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
135397	BRD-K90333595	HT29	2.22 uM	24 h	0.23	0.96	0.07	0.32	1.14	0.86
135435	BRD-K90333595	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	0.38	1.33	1.72
135469	BRD-K90333595	MCF??7.00	0.74 uM	24 h	-0.32	-1.32	0.82	0.17	0.59	0.0

Summary