CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04206
Pert ID:	BRD-K55930204
Compound Name:	phenytoin
Targets:	SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A
MoA:	hydantoin antiepileptic
SMILES:	O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
50027	BRD-K55930204	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50380	BRD-K55930204	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
51045	BRD-K55930204	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90981	BRD-K55930204	HUH7	12.5 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
99675	BRD-K55930204	U2OS	20 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
123787	BRD-K55930204	A375	0.125 uM	24 h	0.3	1.25	0.56	0.25	0.87	0.18
123885	BRD-K55930204	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123984	BRD-K55930204	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124040	BRD-K55930204	MCF10A	10 uM	24 h	0.19	0.81	0.0	0.29	1.03	0.52
124167	BRD-K55930204	THP1	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124220	BRD-K55930204	YAPC	10 uM	24 h	-0.19	-0.78	0.0	0.0	0.0	0.0
132159	BRD-K55930204	HA1E	0.08 uM	24 h	0.18	0.76	0.0	0.0	0.0	0.0
132187	BRD-K55930204	HELA	0.01 uM	24 h	0.26	1.08	0.21	0.3	1.06	0.61
132218	BRD-K55930204	HT29	0.08 uM	24 h	0.31	1.27	0.58	0.0	0.0	0.0
132248	BRD-K55930204	MCF??7.00	0.08 uM	24 h	-0.2	-0.84	0.01	-0.24	-0.8	0.12
132270	BRD-K55930204	MDAMB231	0.01 uM	24 h	0.32	1.32	0.82	-0.29	-0.98	0.5
132287	BRD-K55930204	PC3	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary