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CMap Candidate Details

Structure:
CMap ID: C04237
Pert ID: BRD-K66874953
Compound Name: pifithrin-alpha
Targets: TP53
MoA: TP53 inhibitor
SMILES: Cc1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4462 BRD-K66874953 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8967 BRD-K66874953 A375 70 uM 24 h 0.0 0.0 0.0 -0.42 -1.41 2.02
9221 BRD-K66874953 A549 70 uM 6 h 0.23 0.96 0.08 -0.27 -0.92 0.34
9476 BRD-K66874953 AGS 70 uM 6 h 0.0 0.0 0.0 -0.23 -0.77 0.08
9781 BRD-K66874953 H1299 70 uM 6 h 0.0 0.0 0.0 -0.21 -0.71 0.03
9905 BRD-K66874953 HA1E 70 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
10564 BRD-K66874953 HCT116 70 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.72
10997 BRD-K66874953 HT29 70 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
11162 BRD-K66874953 MCF??7.00 70 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11541 BRD-K66874953 NCIH2073 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11808 BRD-K66874953 NCIH508 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12101 BRD-K66874953 NCIH596 70 uM 6 h 0.0 0.0 0.0 -0.26 -0.87 0.23
12473 BRD-K66874953 PC3 70 uM 24 h -0.34 -1.42 1.43 -0.28 -0.94 0.38
12841 BRD-K66874953 SW480 70 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.15
12987 BRD-K66874953 THP1 70 uM 6 h 0.0 0.0 0.0 -0.25 -0.83 0.16
13326 BRD-K66874953 U937 70 uM 6 h 0.2 0.85 0.01 0.25 0.88 0.18
13655 BRD-K66874953 VCAP 70 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37715 BRD-K66874953 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37933 BRD-K66874953 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38537 BRD-K66874953 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38990 BRD-K66874953 SKB 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
99355 BRD-K66874953 U2OS 15 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).