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CMap Candidate Details

Structure:
CMap ID: C04246
Pert ID: BRD-K49456274
Compound Name: pilaralisib
Targets:
MoA: PI3K inhibitor
SMILES: COc1ccc(Cl)c(Nc2nc3ccccc3nc2NS(=O)(=O)c2cccc(NC(=O)C(C)(C)N)c2)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
58 BRD-K49456274 BJAB 10 uM 4 h 0.2 0.82 0.0 0.0 0.0 0.0
92 BRD-K49456274 HBL1 0.66 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.97
128 BRD-K49456274 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
182 BRD-K49456274 KMS34 0.66 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
222 BRD-K49456274 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
261 BRD-K49456274 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
313 BRD-K49456274 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
336 BRD-K49456274 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
380 BRD-K49456274 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.37 1.29 1.49
407 BRD-K49456274 THP1 2.5 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
465 BRD-K49456274 TMD8 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
95310 BRD-K49456274 A549 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
95356 BRD-K49456274 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95445 BRD-K49456274 U2OS 0.12 uM 48 h 0.0 0.0 0.0 0.24 0.86 0.16
125597 BRD-K49456274 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125634 BRD-K49456274 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.4 2.02
125683 BRD-K49456274 HELA 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.04
125702 BRD-K49456274 HT29 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
125754 BRD-K49456274 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125788 BRD-K49456274 JURKAT 1.11 uM 24 h -0.23 -0.97 0.11 0.37 1.3 1.49
125858 BRD-K49456274 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
125881 BRD-K49456274 PC3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
125952 BRD-K49456274 YAPC 1.11 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
133743 BRD-K49456274 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133869 BRD-K49456274 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).