CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04247
Pert ID:	BRD-K85090592
Compound Name:	pilocarpine
Targets:	CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5
MoA:	acetylcholine receptor agonist
SMILES:	CC[C@H]1[C@@H](Cc2cncn2C)COC1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
24817	BRD-K85090592	HA1E	10 uM	6 h	0.0	0.0	0.0	0.3	1.06	0.58
25539	BRD-K85090592	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.24	-0.82	0.14
91097	BRD-K85090592	HUH7	15 uM	72 h	0.28	1.18	0.39	-0.32	-1.08	0.8
125568	BRD-K85090592	A375	0.04 uM	24 h	0.21	0.89	0.02	0.26	0.92	0.25
125606	BRD-K85090592	A549	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125669	BRD-K85090592	HELA	1.11 uM	24 h	0.23	0.98	0.09	-0.25	-0.83	0.17
125717	BRD-K85090592	HUVEC	3.33 uM	24 h	0.34	1.43	1.1	0.0	0.0	0.0
125766	BRD-K85090592	JURKAT	0.04 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.71
125821	BRD-K85090592	MCF??7.00	10 uM	24 h	-0.25	-1.02	0.18	0.24	0.87	0.17
125845	BRD-K85090592	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125866	BRD-K85090592	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125890	BRD-K85090592	THP1	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125916	BRD-K85090592	YAPC	10 uM	24 h	0.0	0.0	0.0	0.31	1.09	0.67
133727	BRD-K85090592	HEK293	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133789	BRD-K85090592	HT29	0.74 uM	24 h	0.0	0.0	0.0	-0.39	-1.31	1.69
133846	BRD-K85090592	MCF10A	0.74 uM	24 h	0.0	0.0	0.0	-0.23	-0.76	0.07

Summary