CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04253
Pert ID:	BRD-A84575140
Compound Name:	pimobendan
Targets:	PDE3A
MoA:	calcium sensitizer; phosphodiesterase inhibitor
SMILES:	COc1ccc(cc1)-c1nc2cc(ccc2[nH]1)C1=NNC(=O)CC1C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125565	BRD-A84575140	A375	10 uM	24 h	0.3	1.26	0.56	-0.22	-0.73	0.05
125638	BRD-A84575140	HEK293	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125668	BRD-A84575140	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125714	BRD-A84575140	HUVEC	10 uM	24 h	-0.26	-1.1	0.33	-0.31	-1.04	0.66
125764	BRD-A84575140	JURKAT	10 uM	24 h	0.21	0.88	0.02	0.0	0.0	0.0
125820	BRD-A84575140	MCF??7.00	10 uM	24 h	0.21	0.89	0.02	0.0	0.0	0.0
125913	BRD-A84575140	YAPC	3.33 uM	24 h	0.28	1.15	0.33	-0.3	-1.0	0.53
133658	BRD-A84575140	A549	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133686	BRD-A84575140	HA1E	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133787	BRD-A84575140	HT29	0.03 uM	24 h	0.0	0.0	0.0	0.37	1.3	1.54
133844	BRD-A84575140	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133902	BRD-A84575140	MDAMB231	0.74 uM	24 h	0.19	0.79	0.0	0.23	0.8	0.08
133933	BRD-A84575140	PC3	0.08 uM	24 h	0.28	1.15	0.32	0.35	1.22	1.18
133964	BRD-A84575140	THP1	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary