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CMap Candidate Details

Structure:
CMap ID: C04258
Pert ID: BRD-A70998768
Compound Name: pinaverium
Targets: CACNA1C
MoA: T-type calcium channel blocker
SMILES: COc1cc(Br)c(C[N+]2(CCOCCC3CC[C@H]4C[C@@H]3C4(C)C)CCOCC2)cc1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126632 BRD-A70998768 A375 1.11 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
126654 BRD-A70998768 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126677 BRD-A70998768 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126698 BRD-A70998768 HEK293 3.33 uM 24 h -0.3 -1.25 0.7 0.3 1.05 0.58
126725 BRD-A70998768 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126746 BRD-A70998768 HT29 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
126848 BRD-A70998768 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126892 BRD-A70998768 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126918 BRD-A70998768 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126960 BRD-A70998768 THP1 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.97
126999 BRD-A70998768 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134874 BRD-A70998768 HUVEC 0.03 uM 24 h -0.29 -1.19 0.54 0.0 0.0 0.0
134902 BRD-A70998768 JURKAT 0.03 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
134931 BRD-A70998768 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).