CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04260
Pert ID:	BRD-A97701745
Compound Name:	pindolol
Targets:	ADRB1\|ADRB2\|HTR1A\|HTR1B\|HTR2A\|HTR2B
MoA:	adrenergic receptor antagonist
SMILES:	CC(C)NCC(O)COc1cccc2[nH]ccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5292	BRD-A97701745	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.12
5747	BRD-A97701745	HCC515	10 uM	6 h	-0.19	-0.78	0.0	0.31	1.1	0.68
5871	BRD-A97701745	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
6506	BRD-A97701745	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37571	BRD-A97701745	ASC	10 uM	24 h	0.0	0.0	0.0	0.29	1.03	0.52
38410	BRD-A97701745	NPC	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.59
38900	BRD-A97701745	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91062	BRD-A97701745	HUH7	12.5 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
99935	BRD-A97701745	U2OS	10 uM	6 h	-0.2	-0.83	0.0	0.0	0.0	0.0
127334	BRD-A97701745	A375	0.04 uM	24 h	0.0	0.0	0.0	0.25	0.89	0.2
127379	BRD-A97701745	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127482	BRD-A97701745	HT29	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127494	BRD-A97701745	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127588	BRD-A97701745	PC3	3.33 uM	24 h	0.24	0.99	0.09	0.0	0.0	0.0
127664	BRD-A97701745	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135356	BRD-A97701745	HELA	0.08 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.83
135426	BRD-A97701745	MCF10A	0.03 uM	24 h	0.0	0.0	0.0	-0.29	-0.96	0.44
135460	BRD-A97701745	MCF??7.00	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135489	BRD-A97701745	THP1	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary