CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04282
Pert ID:	BRD-K25224017
Compound Name:	pirenperone
Targets:	HTR2A\|HTR7
MoA:	serotonin receptor antagonist
SMILES:	Cc1nc2ccccn2c(=O)c1CCN1CCC(CC1)C(=O)c1ccc(F)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5196	BRD-K25224017	A375	10 uM	6 h	-0.19	-0.77	0.0	0.32	1.12	0.77
5311	BRD-K25224017	HA1E	10 uM	24 h	0.17	0.71	0.0	-0.3	-1.02	0.61
5763	BRD-K25224017	HCC515	10 uM	6 h	0.29	1.23	0.5	0.0	0.0	0.0
6012	BRD-K25224017	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
6386	BRD-K25224017	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24660	BRD-K25224017	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37620	BRD-K25224017	ASC	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.86	0.21
37882	BRD-K25224017	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.23	-0.79	0.1
38448	BRD-K25224017	NPC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.3
38930	BRD-K25224017	SKB	10 uM	24 h	0.21	0.86	0.01	-0.33	-1.12	0.96
51597	BRD-K25224017	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
51927	BRD-K25224017	PC3	10 uM	6 h	0.0	0.0	0.0	-0.24	-0.82	0.15
99773	BRD-K25224017	U2OS	10 uM	6 h	-0.21	-0.87	0.02	0.28	0.99	0.41

Summary