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CMap Candidate Details

Structure:
CMap ID: C04283
Pert ID: BRD-K89375097
Compound Name: pirenzepine
Targets: CHRM1|CHRM2|CHRM3|CHRM4|CHRM5
MoA: acetylcholine receptor antagonist
SMILES: CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4500 BRD-K89375097 HCC515 10 uM 24 h -0.18 -0.74 0.0 0.29 1.04 0.53
5132 BRD-K89375097 VCAP 10 uM 6 h 0.0 0.0 0.0 0.39 1.38 2.16
37756 BRD-K89375097 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37953 BRD-K89375097 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38571 BRD-K89375097 NPC 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
38791 BRD-K89375097 PHH 10 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
91101 BRD-K89375097 HUH7 10 uM 72 h 0.0 0.0 0.0 -0.26 -0.86 0.21
127734 BRD-K89375097 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127776 BRD-K89375097 A549 1.11 uM 24 h 0.21 0.89 0.02 -0.17 -0.59 0.0
127816 BRD-K89375097 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127855 BRD-K89375097 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127929 BRD-K89375097 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127983 BRD-K89375097 MCF10A 10 uM 24 h -0.2 -0.84 0.0 0.29 1.02 0.47
128024 BRD-K89375097 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128045 BRD-K89375097 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128072 BRD-K89375097 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
135556 BRD-K89375097 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
135604 BRD-K89375097 HT29 0.01 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
135647 BRD-K89375097 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).