CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04286
Pert ID:	BRD-K47936004
Compound Name:	piribedil
Targets:	ADRA1A\|ADRA2A\|ADRA2C\|DRD2\|DRD3\|DRD4\|HTR1A\|HTR2B
MoA:	dopamine receptor agonist
SMILES:	C(N1CCN(CC1)c1ncccn1)c1ccc2OCOc2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6884	BRD-K47936004	A375	10 uM	6 h	0.0	0.0	0.0	-0.33	-1.1	0.88
7161	BRD-K47936004	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25376	BRD-K47936004	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91134	BRD-K47936004	HUH7	12 uM	72 h	0.0	0.0	0.0	-0.23	-0.79	0.1
99585	BRD-K47936004	U2OS	10 uM	6 h	0.0	0.0	0.0	0.22	0.78	0.07
125680	BRD-K47936004	HELA	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125750	BRD-K47936004	HUVEC	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125785	BRD-K47936004	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125833	BRD-K47936004	MCF??7.00	1.11 uM	24 h	0.21	0.87	0.01	-0.3	-1.0	0.55
125900	BRD-K47936004	THP1	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125948	BRD-K47936004	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133711	BRD-K47936004	HA1E	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133741	BRD-K47936004	HEK293	0.74 uM	24 h	0.28	1.18	0.39	0.0	0.0	0.0
133807	BRD-K47936004	HT29	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133866	BRD-K47936004	MCF10A	0.01 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.05
133924	BRD-K47936004	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.56
133953	BRD-K47936004	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary