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CMap Candidate Details

Structure:
CMap ID: C04308
Pert ID: BRD-A41451487
Compound Name: PK-11195
Targets: TSPO
MoA: benzodiazepine receptor antagonist
SMILES: CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3684 BRD-A41451487 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8874 BRD-A41451487 A375 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9072 BRD-A41451487 A549 150 uM 24 h -0.23 -0.94 0.08 -0.32 -1.08 0.8
9291 BRD-A41451487 AGS 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9873 BRD-A41451487 HA1E 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10114 BRD-A41451487 HCC515 150 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.89
10400 BRD-A41451487 HCT116 150 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.28
10667 BRD-A41451487 HEPG2 150 uM 6 h 0.18 0.74 0.0 0.0 0.0 0.0
10905 BRD-A41451487 HT29 150 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11126 BRD-A41451487 MCF??7.00 150 uM 24 h -0.22 -0.93 0.07 -0.29 -0.97 0.47
11341 BRD-A41451487 NCIH2073 150 uM 6 h 0.0 0.0 0.0 0.23 0.83 0.12
11913 BRD-A41451487 NCIH596 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12666 BRD-A41451487 SW480 150 uM 6 h 0.26 1.08 0.22 0.0 0.0 0.0
13147 BRD-A41451487 U937 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44766 BRD-A41451487 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45885 BRD-A41451487 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46201 BRD-A41451487 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46516 BRD-A41451487 SKB 10 uM 24 h -0.22 -0.93 0.07 -0.25 -0.84 0.17
123398 BRD-A41451487 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123423 BRD-A41451487 PC3 0.04 uM 24 h 0.24 1.0 0.1 0.17 0.62 0.0
131630 BRD-A41451487 HEK293 0.25 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
131663 BRD-A41451487 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131728 BRD-A41451487 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131782 BRD-A41451487 JURKAT 0.25 uM 24 h 0.25 1.04 0.14 -0.36 -1.2 1.19
131826 BRD-A41451487 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131935 BRD-A41451487 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131956 BRD-A41451487 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.2 0.69 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).