CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04337
Pert ID:	BRD-K44227013
Compound Name:	ponatinib
Targets:	ABL1\|BCR\|FGFR1\|FGFR2\|FGFR3\|FGFR4\|FLT3\|KDR\|KIT\|LCK\|LYN\|PDGFRA\|RET\|SRC\|TEK
MoA:	Bcr-Abl kinase inhibitor; FLT3 inhibitor; PDGFR tyrosine kinase receptor inhibitor
SMILES:	CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1163	BRD-K44227013	MCF??7.00	1.11 uM	24 h	0.0	0.0	0.0
1197	BRD-K44227013	PC3	1.11 uM	24 h	0.0	0.0	0.0
1268	BRD-K44227013	A549	0.12 uM	6 h	0.0	0.0	0.0
1375	BRD-K44227013	U2OS	1.11 uM	48 h	0.0	0.0	0.0
90880	BRD-K44227013	MCF10A	3.33 uM	3 h	0.0	0.0	0.0
91807	BRD-K44227013	HS578T	10 uM	6 h	0.0	0.0	0.0
91892	BRD-K44227013	MDAMB231	10 uM	24 h	0.25	0.89	0.21
91961	BRD-K44227013	SKBR3	10 uM	6 h	-0.31	-1.05	0.7
94409	BRD-K44227013	A375	3.33 uM	24 h	0.23	0.82	0.1
94474	BRD-K44227013	ASC	3.33 uM	24 h	0.0	0.0	0.0
94540	BRD-K44227013	CD34	0.37 uM	24 h	0.0	0.0	0.0
94590	BRD-K44227013	HCC515	1.11 uM	24 h	0.0	0.0	0.0
94631	BRD-K44227013	HEK293	10 uM	24 h	0.27	0.97	0.35
94682	BRD-K44227013	HELA	10 uM	24 h	0.0	0.0	0.0
94734	BRD-K44227013	HME1	10 uM	24 h	0.27	0.94	0.29
94784	BRD-K44227013	HT29	3.33 uM	24 h	0.0	0.0	0.0
94827	BRD-K44227013	HUVEC	10 uM	24 h	0.31	1.08	0.67
94880	BRD-K44227013	JURKAT	10 uM	24 h	0.0	0.0	0.0
95007	BRD-K44227013	NEU	0.04 uM	24 h	0.0	0.0	0.0
95050	BRD-K44227013	NPC	1.11 uM	24 h	0.0	0.0	0.0
95153	BRD-K44227013	SHSY5Y	10 uM	24 h	0.24	0.84	0.12
95231	BRD-K44227013	SKL	10 uM	24 h	0.41	1.44	2.21
95264	BRD-K44227013	THP1	10 uM	24 h	0.0	0.0	0.0

Summary