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CMap Candidate Details

Structure:
CMap ID: C04340
Pert ID: BRD-K46556543
Compound Name: potassium-canrenoate
Targets: NR3C2
MoA: mineralocorticoid receptor antagonist
SMILES: C[C@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@]2(O)CCC(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4224 BRD-K46556543 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4437 BRD-K46556543 HCC515 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
4692 BRD-K46556543 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5091 BRD-K46556543 VCAP 10 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.32
44407 BRD-K46556543 A375 10 uM 6 h 0.0 0.0 0.0 0.3 1.05 0.58
44711 BRD-K46556543 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44972 BRD-K46556543 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45267 BRD-K46556543 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45536 BRD-K46556543 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45701 BRD-K46556543 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46088 BRD-K46556543 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46403 BRD-K46556543 PHH 10 uM 24 h -0.22 -0.94 0.07 -0.3 -1.0 0.53
46726 BRD-K46556543 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).