CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04357
Pert ID:	BRD-K06388322
Compound Name:	pramipexole
Targets:	ADRA2A\|ADRA2B\|ADRA2C\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HTR1A\|HTR1B\|HTR1D\|HTR2A\|HTR2B\|HTR2C
MoA:	dopamine receptor agonist
SMILES:	CCCN[C@H]1CCc2nc(N)sc2C1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1441	BRD-K06388322	NPC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24551	BRD-K06388322	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24869	BRD-K06388322	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25487	BRD-K06388322	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
91242	BRD-K06388322	HUH7	15 uM	72 h	-0.23	-0.96	0.1	0.31	1.11	0.72
122544	BRD-K06388322	A375	0.04 uM	24 h	-0.23	-0.96	0.1	-0.27	-0.91	0.3
122632	BRD-K06388322	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.27
122717	BRD-K06388322	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130912	BRD-K06388322	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130963	BRD-K06388322	HELA	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131039	BRD-K06388322	HUVEC	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131081	BRD-K06388322	MCF??7.00	0.25 uM	24 h	0.29	1.22	0.48	0.0	0.0	0.0
131116	BRD-K06388322	MDAMB231	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131149	BRD-K06388322	PC3	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131182	BRD-K06388322	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary