CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04361
Pert ID:	BRD-K97045029
Compound Name:	pranlukast
Targets:	CYSLTR1\|CYSLTR2\|IL5\|MUC2\|NFKB1\|RNASE3\|TNF
MoA:	leukotriene receptor antagonist
SMILES:	O=C(Nc1cccc2c1oc(cc2=O)-c1nnn[nH]1)c1ccc(OCCCCc2ccccc2)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91037	BRD-K97045029	HUH7	6.66 uM	72 h	-0.38	-1.59	15.35	0.0	0.0	0.0
128400	BRD-K97045029	A549	0.04 uM	24 h	0.0	0.0	0.0	-0.34	-1.15	1.06
128460	BRD-K97045029	HEK293	0.37 uM	24 h	-0.23	-0.97	0.11	-0.24	-0.82	0.15
128516	BRD-K97045029	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128570	BRD-K97045029	JURKAT	0.04 uM	24 h	-0.28	-1.15	0.43	0.27	0.96	0.34
128604	BRD-K97045029	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128613	BRD-K97045029	MCF??7.00	1.11 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.17
128662	BRD-K97045029	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128780	BRD-K97045029	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.35	1.23	1.19
136199	BRD-K97045029	A375	0.03 uM	24 h	-0.32	-1.34	0.98	0.22	0.77	0.06
136244	BRD-K97045029	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136277	BRD-K97045029	HELA	0.01 uM	24 h	0.28	1.18	0.39	0.0	0.0	0.0
136373	BRD-K97045029	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary