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CMap Candidate Details

Structure:
CMap ID: C04366
Pert ID: BRD-K60511616
Compound Name: pravastatin
Targets: HMGCR|SLCO1B1
MoA: HMGCR inhibitor
SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@@H]12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3044 BRD-K60511616 HA1E 10 uM 6 h -0.21 -0.87 0.02 -0.25 -0.83 0.17
3244 BRD-K60511616 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3977 BRD-K60511616 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24462 BRD-K60511616 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24593 BRD-K60511616 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24930 BRD-K60511616 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25035 BRD-K60511616 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25256 BRD-K60511616 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42412 BRD-K60511616 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42729 BRD-K60511616 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.86 0.22
43593 BRD-K60511616 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43897 BRD-K60511616 PHH 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
44153 BRD-K60511616 SKB 10 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
98409 BRD-K60511616 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99715 BRD-K60511616 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).