CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04389
Pert ID:	BRD-K32247306
Compound Name:	primidone
Targets:	CHRNA4\|CHRNA7\|GABRA1\|GABRA2\|GABRA3\|GABRA4\|GABRA5\|GABRA6\|GABRB1\|GABRB2\|GABRB3\|GABRD\|GABRE\|GABRG1\|GABRG2\|GABRG3\|GABRP\|GABRQ\|GRIA2\|GRIK2\|SCN10A\|SCN11A\|SCN1A\|SCN2A\|SCN3A\|SCN4A\|SCN5A\|SCN7A\|SCN8A\|SCN9A
MoA:	GABA receptor antagonist
SMILES:	CCC1(C(=O)NCNC1=O)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5315	BRD-K32247306	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5610	BRD-K32247306	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5900	BRD-K32247306	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37634	BRD-K32247306	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38073	BRD-K32247306	HT29	10 uM	6 h	-0.2	-0.85	0.01	-0.21	-0.72	0.04
38940	BRD-K32247306	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
51141	BRD-K32247306	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
120517	BRD-K32247306	A375	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120552	BRD-K32247306	A549	1.11 uM	24 h	-0.3	-1.24	0.64	0.26	0.91	0.24
120703	BRD-K32247306	JURKAT	10 uM	24 h	-0.23	-0.95	0.09	-0.33	-1.1	0.87
120809	BRD-K32247306	YAPC	3.33 uM	24 h	-0.27	-1.12	0.39	-0.28	-0.95	0.4
129019	BRD-K32247306	HELA	0.03 uM	24 h	0.23	0.95	0.06	0.49	1.72	2.56
129052	BRD-K32247306	MCF??7.00	0.08 uM	24 h	0.0	0.0	0.0	0.29	1.03	0.5
129077	BRD-K32247306	PC3	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary