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CMap Candidate Details

Structure:
CMap ID: C04395
Pert ID: BRD-K95237249
Compound Name: probenecid
Targets: PANX1|SLC22A11|SLC22A6|SLC22A8|SLCO1C1
MoA: uricosuric blocker
SMILES: CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4504 BRD-K95237249 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5137 BRD-K95237249 VCAP 10 uM 6 h -0.3 -1.27 0.74 0.28 1.01 0.44
37200 BRD-K95237249 A375 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
37765 BRD-K95237249 ASC 10 uM 24 h -0.29 -1.19 0.53 0.0 0.0 0.0
37960 BRD-K95237249 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.16 1.11
38577 BRD-K95237249 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
38798 BRD-K95237249 PHH 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
128389 BRD-K95237249 A549 0.04 uM 24 h -0.29 -1.23 0.62 0.34 1.19 1.03
128444 BRD-K95237249 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128507 BRD-K95237249 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128554 BRD-K95237249 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128646 BRD-K95237249 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
128726 BRD-K95237249 THP1 10 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
136230 BRD-K95237249 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136266 BRD-K95237249 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.96
136314 BRD-K95237249 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
136347 BRD-K95237249 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136368 BRD-K95237249 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136386 BRD-K95237249 YAPC 0.25 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).