CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04408
Pert ID:	BRD-K64994968
Compound Name:	progesterone
Targets:	CATSPER1\|CATSPER2\|CATSPER3\|CATSPER4\|CYP17A1\|ESR1\|NR3C2\|OPRK1\|PGR\|TRPC5
MoA:	progesterone receptor agonist
SMILES:	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4585	BRD-K64994968	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.21	-0.69	0.03
24466	BRD-K64994968	A375	10 uM	6 h	0.0	0.0	0.0	0.29	1.03	0.52
24597	BRD-K64994968	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
24799	BRD-K64994968	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
24934	BRD-K64994968	HT29	10 uM	6 h	0.0	0.0	0.0	0.35	1.23	1.19
25102	BRD-K64994968	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	-0.21	-0.72	0.04
25257	BRD-K64994968	PC3	10 uM	6 h	0.0	0.0	0.0	0.33	1.15	0.89
25525	BRD-K64994968	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.23	-0.76	0.07
39737	BRD-K64994968	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40032	BRD-K64994968	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40845	BRD-K64994968	NEU	10 uM	24 h	-0.21	-0.89	0.04	-0.44	-1.48	15.35
41492	BRD-K64994968	SKB	10 uM	24 h	-0.25	-1.05	0.24	-0.3	-1.01	0.56
53251	BRD-K64994968	MCF10A	100 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91370	BRD-K64994968	HUH7	10 uM	72 h	0.25	1.03	0.13	0.25	0.9	0.22
99172	BRD-K64994968	NPC	10 uM	24 h	0.0	0.0	0.0	-0.48	-1.62	15.65
99339	BRD-K64994968	U2OS	6.66 uM	6 h	0.21	0.87	0.01	0.26	0.93	0.27

Summary