CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04411
Pert ID:	BRD-K28183345
Compound Name:	proguanil
Targets:	DHFR
MoA:	dihydrofolate reductase inhibitor
SMILES:	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4210	BRD-K28183345	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
4405	BRD-K28183345	HCC515	10 uM	24 h	-0.31	-1.31	0.82	-0.28	-0.95	0.41
5064	BRD-K28183345	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.42	-1.43	15.35
37138	BRD-K28183345	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37374	BRD-K28183345	A549	10 uM	6 h	0.22	0.92	0.04	0.0	0.0	0.0
37626	BRD-K28183345	ASC	10 uM	24 h	-0.25	-1.04	0.21	-0.26	-0.88	0.26
37887	BRD-K28183345	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38193	BRD-K28183345	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.96	0.43
38453	BRD-K28183345	NPC	10 uM	24 h	0.19	0.81	0.0	0.0	0.0	0.0
38702	BRD-K28183345	PHH	10 uM	24 h	-0.24	-1.01	0.16	0.0	0.0	0.0
38935	BRD-K28183345	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120047	BRD-K28183345	HELA	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120098	BRD-K28183345	HT29	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120179	BRD-K28183345	PC3	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120212	BRD-K28183345	YAPC	0.04 uM	24 h	-0.27	-1.12	0.38	0.0	0.0	0.0

Summary