CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04415
Pert ID:	BRD-A46335897
Compound Name:	promethazine
Targets:	ADRA1A\|CALM1\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD2\|HRH1\|HTR2A
MoA:	histamine receptor antagonist
SMILES:	CC(CN1c2ccccc2Sc2ccccc12)N(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
8876	BRD-A46335897	A375	6.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
9145	BRD-A46335897	A549	6.66 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
9913	BRD-A46335897	HA1E	6.66 uM	24 h	0.0	0.0	0.0	0.26	0.91	0.24
10291	BRD-A46335897	HCC515	6.66 uM	6 h	0.0	0.0	0.0	-0.22	-0.75	0.06
10907	BRD-A46335897	HT29	6.66 uM	24 h	0.0	0.0	0.0	-0.34	-1.14	1.02
11166	BRD-A46335897	MCF??7.00	6.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
11344	BRD-A46335897	NCIH2073	6.66 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11916	BRD-A46335897	NCIH596	6.66 uM	6 h	0.25	1.05	0.16	0.23	0.81	0.09
12480	BRD-A46335897	PC3	6.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
12668	BRD-A46335897	SW480	6.66 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13150	BRD-A46335897	U937	6.66 uM	6 h	0.0	0.0	0.0	-0.31	-1.03	0.62
13537	BRD-A46335897	VCAP	6.66 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
52790	BRD-A46335897	HEPG2	40 uM	24 h	0.17	0.71	0.0	0.34	1.19	1.03
53277	BRD-A46335897	MCF10A	100 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
90978	BRD-A46335897	HUH7	12 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary