CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04422
Pert ID:	BRD-K59273480
Compound Name:	propentofylline
Targets:	PDE1A
MoA:	adenosine reuptake inhibitor; phosphodiesterase inhibitor
SMILES:	CCCn1cnc2n(C)c(=O)n(CCCCC(C)=O)c(=O)c12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6898	BRD-K59273480	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
7698	BRD-K59273480	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.31	-1.03	0.62
8713	BRD-K59273480	VCAP	10 uM	24 h	-0.22	-0.91	0.05	0.29	1.03	0.49
99703	BRD-K59273480	U2OS	10 uM	6 h	0.0	0.0	0.0	0.24	0.83	0.12
123846	BRD-K59273480	A549	3.33 uM	24 h	-0.2	-0.85	0.01	0.23	0.82	0.1
123912	BRD-K59273480	HEK293	10 uM	24 h	0.0	0.0	0.0	0.28	1.01	0.44
123951	BRD-K59273480	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124013	BRD-K59273480	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124066	BRD-K59273480	MCF10A	0.125 uM	24 h	-0.23	-0.95	0.09	0.0	0.0	0.0
124133	BRD-K59273480	MDAMB231	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.7
124195	BRD-K59273480	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.39
124247	BRD-K59273480	YAPC	1.11 uM	24 h	0.19	0.79	0.0	0.0	0.0	0.0
132171	BRD-K59273480	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132236	BRD-K59273480	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132260	BRD-K59273480	MCF??7.00	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132304	BRD-K59273480	PC3	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary