Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C04442
Pert ID: BRD-K42098891
Compound Name: protriptyline
Targets: SLC6A2|SLC6A4
MoA: tricyclic antidepressant
SMILES: CNCCCC1c2ccccc2C=Cc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5629 BRD-K42098891 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6547 BRD-K42098891 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37656 BRD-K42098891 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37902 BRD-K42098891 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.31 1.11 0.71
38481 BRD-K42098891 NPC 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.17
38721 BRD-K42098891 PHH 10 uM 24 h -0.22 -0.91 0.05 -0.31 -1.05 0.72
52159 BRD-K42098891 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123241 BRD-K42098891 A375 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
123277 BRD-K42098891 HA1E 10 uM 24 h 0.24 1.01 0.12 0.29 1.03 0.51
123317 BRD-K42098891 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123349 BRD-K42098891 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123401 BRD-K42098891 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
123429 BRD-K42098891 PC3 10 uM 24 h 0.22 0.91 0.03 0.36 1.26 1.29
123466 BRD-K42098891 THP1 10 uM 24 h -0.24 -0.99 0.14 0.0 0.0 0.0
123498 BRD-K42098891 YAPC 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
131555 BRD-K42098891 A549 0.74 uM 24 h -0.18 -0.73 0.0 0.0 0.0 0.0
131637 BRD-K42098891 HEK293 0.25 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
131735 BRD-K42098891 HUVEC 0.25 uM 24 h -0.29 -1.22 0.62 -0.38 -1.29 1.53
131789 BRD-K42098891 JURKAT 2.22 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
131828 BRD-K42098891 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).