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CMap Candidate Details

Structure:
CMap ID: C04471
Pert ID: BRD-K73397362
Compound Name: purmorphamine
Targets: SMO
MoA: smoothened receptor agonist
SMILES: C1CCC(CC1)n1cnc2c(Nc3ccc(cc3)N3CCOCC3)nc(Oc3cccc4ccccc34)nc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1965 BRD-K73397362 HCC515 10 uM 24 h -0.27 -1.14 0.42 -0.34 -1.14 1.02
2266 BRD-K73397362 PC3 10 uM 24 h -0.24 -1.01 0.16 -0.31 -1.05 0.7
2607 BRD-K73397362 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8977 BRD-K73397362 A375 40 uM 24 h -0.19 -0.8 0.0 -0.3 -1.0 0.52
9115 BRD-K73397362 A549 40 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
9801 BRD-K73397362 H1299 40 uM 6 h -0.2 -0.82 0.0 0.0 0.0 0.0
11010 BRD-K73397362 HT29 40 uM 24 h 0.0 0.0 0.0 -0.38 -1.3 1.57
11564 BRD-K73397362 NCIH2073 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11828 BRD-K73397362 NCIH508 40 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.42
12121 BRD-K73397362 NCIH596 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12858 BRD-K73397362 SW480 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13017 BRD-K73397362 THP1 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42463 BRD-K73397362 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42774 BRD-K73397362 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43641 BRD-K73397362 NPC 10 uM 24 h -0.25 -1.03 0.2 -0.35 -1.19 1.15
43940 BRD-K73397362 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44195 BRD-K73397362 SKB 10 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
90613 BRD-K73397362 HCT116 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90682 BRD-K73397362 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
97983 BRD-K73397362 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
98016 BRD-K73397362 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
98056 BRD-K73397362 P1A82 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).