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CMap Candidate Details

Structure:
CMap ID: C04473
Pert ID: BRD-K50836978
Compound Name: purvalanol-a
Targets: CDK1|CDK2|CDK4|CDK5|CSNK1G3|RPS6KA1|SRC
MoA: CDK inhibitor
SMILES: CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6888 BRD-K50836978 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7171 BRD-K50836978 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7337 BRD-K50836978 HA1E 10 uM 24 h -0.24 -0.99 0.14 0.0 0.0 0.0
7677 BRD-K50836978 HCC515 10 uM 6 h -0.23 -0.95 0.09 -0.31 -1.05 0.72
8008 BRD-K50836978 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8141 BRD-K50836978 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8383 BRD-K50836978 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8826 BRD-K50836978 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97315 BRD-K50836978 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99621 BRD-K50836978 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).