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CMap Candidate Details

Structure:
CMap ID: C04492
Pert ID: BRD-K88429204
Compound Name: pyrimethamine
Targets: DHFR|SLC47A1
MoA: dihydrofolate reductase inhibitor
SMILES: CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4498 BRD-K88429204 HCC515 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
4726 BRD-K88429204 PC3 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
4968 BRD-K88429204 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.17
37753 BRD-K88429204 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38568 BRD-K88429204 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38788 BRD-K88429204 PHH 10 uM 24 h 0.21 0.87 0.01 -0.33 -1.12 0.93
39016 BRD-K88429204 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52986 BRD-K88429204 HEPG2 40 uM 3 h 0.0 0.0 0.0 -0.28 -0.93 0.36
96463 BRD-K88429204 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127769 BRD-K88429204 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127810 BRD-K88429204 HA1E 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
127846 BRD-K88429204 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127896 BRD-K88429204 HT29 10 uM 24 h -0.18 -0.74 0.0 0.22 0.77 0.06
127920 BRD-K88429204 HUVEC 0.125 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
127974 BRD-K88429204 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
128020 BRD-K88429204 MCF??7.00 10 uM 24 h -0.3 -1.26 0.71 -0.22 -0.75 0.06
128066 BRD-K88429204 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135547 BRD-K88429204 HELA 2.22 uM 24 h 0.31 1.28 0.62 -0.23 -0.79 0.11
135638 BRD-K88429204 JURKAT 2.22 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).