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CMap Candidate Details

Structure:
CMap ID: C04509
Pert ID: BRD-K68867920
Compound Name: quetiapine
Targets: ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2C|HTR3A|HTR6|HTR7|SLC6A2
MoA: dopamine receptor antagonist; serotonin receptor antagonist
SMILES: OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1458 BRD-K68867920 NPC 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5674 BRD-K68867920 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
24601 BRD-K68867920 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25410 BRD-K68867920 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37719 BRD-K68867920 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37935 BRD-K68867920 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38764 BRD-K68867920 PHH 10 uM 24 h 0.21 0.89 0.02 0.23 0.82 0.1
126623 BRD-K68867920 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126710 BRD-K68867920 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126737 BRD-K68867920 HT29 10 uM 24 h 0.26 1.1 0.24 0.29 1.03 0.51
126764 BRD-K68867920 JURKAT 10 uM 24 h -0.22 -0.91 0.05 -0.29 -0.97 0.46
126832 BRD-K68867920 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126909 BRD-K68867920 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126936 BRD-K68867920 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134721 BRD-K68867920 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134756 BRD-K68867920 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134851 BRD-K68867920 HUVEC 2.22 uM 24 h 0.23 0.96 0.07 -0.38 -1.27 1.43
134919 BRD-K68867920 MCF10A 2.22 uM 24 h 0.3 1.24 0.53 -0.28 -0.94 0.37
134938 BRD-K68867920 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134986 BRD-K68867920 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).