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CMap Candidate Details

Structure:
CMap ID: C04523
Pert ID: BRD-K93918653
Compound Name: quizartinib
Targets: CSF1R|FLT3|KIT|PDGFRA|PDGFRB|RET
MoA: FLT3 inhibitor
SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1351 BRD-K93918653 U2OS 10 uM 48 h -0.17 -0.71 0.0 0.0 0.0 0.0
33529 BRD-K93918653 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36686 BRD-K93918653 SKB 10 uM 24 h 0.22 0.92 0.04 0.26 0.91 0.24
36897 BRD-K93918653 VCAP 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
91561 BRD-K93918653 BT20 10 uM 6 h 0.0 0.0 0.0 -0.48 -1.63 15.65
91591 BRD-K93918653 HS578T 10 uM 24 h 0.22 0.91 0.04 -0.36 -1.21 1.24
91720 BRD-K93918653 MDAMB231 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.26 1.39
91782 BRD-K93918653 SKBR3 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.39 2.02
92946 BRD-K93918653 ASC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
93015 BRD-K93918653 CD34 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
93241 BRD-K93918653 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
93430 BRD-K93918653 NPC 10 uM 24 h 0.34 1.4 1.02 -0.41 -1.39 2.02
93496 BRD-K93918653 SKL 3.33 uM 24 h 0.37 1.54 1.46 -0.39 -1.32 1.71
95991 BRD-K93918653 PHH 1.11 uM 24 h -0.28 -1.18 0.51 0.0 0.0 0.0
117049 BRD-K93918653 A549 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.52
117089 BRD-K93918653 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117130 BRD-K93918653 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117178 BRD-K93918653 HEPG2 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
117263 BRD-K93918653 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
128432 BRD-K93918653 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
128502 BRD-K93918653 HT29 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
128542 BRD-K93918653 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128591 BRD-K93918653 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
128677 BRD-K93918653 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128714 BRD-K93918653 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
128762 BRD-K93918653 YAPC 0.37 uM 24 h -0.25 -1.03 0.2 -0.29 -0.99 0.5
136259 BRD-K93918653 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).