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CMap Candidate Details

Structure:
CMap ID: C04540
Pert ID: BRD-K93123848
Compound Name: RAF265
Targets: BRAF
MoA: RAF inhibitor; VEGFR inhibitor
SMILES: Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
94516 BRD-K93123848 ASC 10 uM 24 h -0.24 -0.99 0.13 -0.31 -1.05 0.7
94562 BRD-K93123848 CD34 3.33 uM 24 h -0.33 -1.39 1.14 -0.24 -0.82 0.15
94608 BRD-K93123848 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94700 BRD-K93123848 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.46 -1.54 15.35
94757 BRD-K93123848 HME1 3.33 uM 24 h 0.24 1.0 0.1 -0.32 -1.07 0.76
94799 BRD-K93123848 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
94849 BRD-K93123848 HUVEC 10 uM 24 h 0.22 0.93 0.05 -0.25 -0.83 0.17
95027 BRD-K93123848 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95093 BRD-K93123848 NPC 10 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
95125 BRD-K93123848 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95175 BRD-K93123848 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95215 BRD-K93123848 SKL 0.12 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
95284 BRD-K93123848 THP1 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.46
128101 BRD-K93123848 A375 0.37 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
128202 BRD-K93123848 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
128252 BRD-K93123848 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128281 BRD-K93123848 MDAMB231 10 uM 24 h 0.29 1.22 0.48 -0.29 -0.96 0.43
135770 BRD-K93123848 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135792 BRD-K93123848 HA1E 2.22 uM 24 h 0.2 0.85 0.01 -0.27 -0.92 0.34
135837 BRD-K93123848 HEK293 0.74 uM 24 h 0.22 0.93 0.05 -0.3 -1.0 0.54
135965 BRD-K93123848 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
136111 BRD-K93123848 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).