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CMap Candidate Details

Structure:
CMap ID: C04541
Pert ID: BRD-K63828191
Compound Name: raloxifene
Targets: ESR1|ESR2
MoA: estrogen receptor antagonist; selective estrogen receptor modulator (SERM)
SMILES: Oc1ccc(cc1)-c1sc2cc(O)ccc2c1C(=O)c1ccc(OCCN2CCCCC2)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1154 BRD-K63828191 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1215 BRD-K63828191 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1399 BRD-K63828191 U2OS 10 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.29
37710 BRD-K63828191 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38532 BRD-K63828191 NPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.34
38759 BRD-K63828191 PHH 10 uM 24 h -0.3 -1.26 0.71 -0.3 -1.02 0.6
38985 BRD-K63828191 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51050 BRD-K63828191 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90992 BRD-K63828191 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
95602 BRD-K63828191 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.9
119271 BRD-K63828191 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119407 BRD-K63828191 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119468 BRD-K63828191 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
119543 BRD-K63828191 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
119575 BRD-K63828191 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
125029 BRD-K63828191 HELA 10 uM 24 h -0.23 -0.95 0.08 0.37 1.29 1.49
125112 BRD-K63828191 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125166 BRD-K63828191 THP1 10 uM 24 h -0.24 -0.98 0.13 -0.32 -1.06 0.74
125208 BRD-K63828191 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133052 BRD-K63828191 HEK293 0.03 uM 24 h -0.23 -0.96 0.1 -0.2 -0.66 0.01
133159 BRD-K63828191 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133199 BRD-K63828191 MCF10A 0.01 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).