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CMap Candidate Details

Structure:
CMap ID: C04542
Pert ID: BRD-K05658747
Compound Name: raltegravir
Targets:
MoA: HIV integrase inhibitor
SMILES: Cc1nnc(o1)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29770 BRD-K05658747 A375 10 uM 6 h 0.0 0.0 0.0 -0.42 -1.43 15.35
30346 BRD-K05658747 ASC 10 uM 24 h 0.2 0.82 0.0 0.0 0.0 0.0
30951 BRD-K05658747 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31252 BRD-K05658747 HEPG2 10 uM 6 h 0.23 0.94 0.06 0.21 0.75 0.04
32337 BRD-K05658747 NPC 10 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
32930 BRD-K05658747 SKB 10 uM 24 h 0.21 0.87 0.01 0.24 0.84 0.12
33420 BRD-K05658747 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.87
122917 BRD-K05658747 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122991 BRD-K05658747 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
123042 BRD-K05658747 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123067 BRD-K05658747 MCF10A 3.33 uM 24 h 0.19 0.79 0.0 -0.22 -0.73 0.04
123132 BRD-K05658747 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123204 BRD-K05658747 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131260 BRD-K05658747 A549 0.74 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.47
131292 BRD-K05658747 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131316 BRD-K05658747 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131379 BRD-K05658747 HUVEC 0.08 uM 24 h -0.29 -1.2 0.55 0.0 0.0 0.0
131448 BRD-K05658747 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.42
131473 BRD-K05658747 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131512 BRD-K05658747 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).