CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04559
Pert ID:	BRD-K76694128
Compound Name:	rebastinib
Targets:	ABL1\|BCR\|FGR\|FLT3\|HCK\|LYN\|SRC
MoA:	Bcr-Abl kinase inhibitor; TIE tyrosine kinase inhibitor; VEGFR inhibitor
SMILES:	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
92870	BRD-K76694128	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92897	BRD-K76694128	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92937	BRD-K76694128	ASC	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93000	BRD-K76694128	CD34	10 uM	24 h	0.27	1.11	0.25	0.0	0.0	0.0
93043	BRD-K76694128	HA1E	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93088	BRD-K76694128	HEK293	10 uM	24 h	-0.17	-0.72	0.0	0.37	1.31	1.59
93130	BRD-K76694128	HELA	10 uM	24 h	0.19	0.81	0.0	0.27	0.94	0.29
93173	BRD-K76694128	HEPG2	1.11 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45
93226	BRD-K76694128	HUVEC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93280	BRD-K76694128	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	0.29	1.04	0.54
93318	BRD-K76694128	MCF10A	10 uM	24 h	-0.24	-0.99	0.14	0.0	0.0	0.0
93361	BRD-K76694128	MDAMB231	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93398	BRD-K76694128	NPC	3.33 uM	24 h	0.0	0.0	0.0	0.32	1.15	0.88
93447	BRD-K76694128	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93512	BRD-K76694128	SKL	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93546	BRD-K76694128	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93586	BRD-K76694128	YAPC	3.33 uM	24 h	0.0	0.0	0.0	0.31	1.1	0.68

Summary