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CMap Candidate Details

Structure:
CMap ID: C04574
Pert ID: BRD-K61567297
Compound Name: resatorvid
Targets: TLR4
MoA: toll-like receptor antagonist
SMILES: CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87311 BRD-K61567297 BJAB 0.01 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87335 BRD-K61567297 HBL1 0.04 uM 24 h -0.23 -0.95 0.09 -0.33 -1.1 0.86
87383 BRD-K61567297 K562 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
87432 BRD-K61567297 KMS34 0.01 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
87494 BRD-K61567297 MINO 0.01 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87534 BRD-K61567297 NALM6 2.5 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
87584 BRD-K61567297 OCILY10 0.01 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
87636 BRD-K61567297 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
87685 BRD-K61567297 OCILY3 0.01 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
87736 BRD-K61567297 SKMEL5 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87798 BRD-K61567297 THP1 0.01 uM 3 h 0.27 1.11 0.25 -0.36 -1.21 1.24
87826 BRD-K61567297 TMD8 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123822 BRD-K61567297 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123863 BRD-K61567297 A549 10 uM 24 h -0.29 -1.23 0.63 0.0 0.0 0.0
123932 BRD-K61567297 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123957 BRD-K61567297 HELA 0.37 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
123978 BRD-K61567297 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
124034 BRD-K61567297 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.44
124085 BRD-K61567297 MCF10A 0.04 uM 24 h -0.22 -0.92 0.06 0.21 0.73 0.03
124111 BRD-K61567297 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
124148 BRD-K61567297 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124268 BRD-K61567297 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132184 BRD-K61567297 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132316 BRD-K61567297 PC3 2.22 uM 24 h 0.24 1.01 0.12 -0.31 -1.04 0.68
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).