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CMap Candidate Details

Structure:
CMap ID: C00459
Pert ID: BRD-K13390322
Compound Name: AT-7519
Targets: CDK1|CDK2|CDK4|CDK5|CDK6|CDK9
MoA: CDK inhibitor
SMILES: Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30368 BRD-K13390322 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30971 BRD-K13390322 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31274 BRD-K13390322 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32359 BRD-K13390322 NPC 10 uM 24 h -0.24 -1.02 0.18 -0.3 -1.02 0.62
32950 BRD-K13390322 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33431 BRD-K13390322 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.06 0.74
91535 BRD-K13390322 BT20 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91571 BRD-K13390322 HS578T 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91641 BRD-K13390322 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91728 BRD-K13390322 SKBR3 0.37 uM 24 h -0.21 -0.89 0.03 -0.25 -0.84 0.18
92562 BRD-K13390322 HME1 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92677 BRD-K13390322 LNCAP 0.12 uM 24 h 0.32 1.33 0.85 0.0 0.0 0.0
92741 BRD-K13390322 MCF10A 0.04 uM 3 h -0.24 -1.01 0.16 0.0 0.0 0.0
95391 BRD-K13390322 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97279 BRD-K13390322 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122253 BRD-K13390322 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122316 BRD-K13390322 HEK293 3.33 uM 24 h 0.2 0.84 0.0 -0.29 -0.96 0.44
122418 BRD-K13390322 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.11
122476 BRD-K13390322 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
122516 BRD-K13390322 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130556 BRD-K13390322 A549 0.74 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
130591 BRD-K13390322 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130667 BRD-K13390322 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130708 BRD-K13390322 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130811 BRD-K13390322 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).