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CMap Candidate Details

Structure:
CMap ID: C04595
Pert ID: BRD-K89391146
Compound Name: RG108
Targets: DNMT1|DNMT3B
MoA: DNA methyltransferase inhibitor
SMILES: OC(=O)[C@H](Cc1c[nH]c2ccccc12)N1C(=O)c2ccccc2C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9068 BRD-K89391146 A375 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9537 BRD-K89391146 AGS 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9843 BRD-K89391146 H1299 80 uM 6 h 0.0 0.0 0.0 -0.34 -1.16 1.1
10375 BRD-K89391146 HCC515 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10870 BRD-K89391146 HEPG2 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11033 BRD-K89391146 HT29 80 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11305 BRD-K89391146 MCF??7.00 80 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.37
11604 BRD-K89391146 NCIH2073 80 uM 6 h 0.0 0.0 0.0 0.24 0.87 0.17
11863 BRD-K89391146 NCIH508 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12399 BRD-K89391146 NOMO1 80 uM 6 h 0.0 0.0 0.0 -0.28 -0.93 0.34
12634 BRD-K89391146 PC3 80 uM 6 h 0.0 0.0 0.0 -0.34 -1.15 1.07
12892 BRD-K89391146 SW480 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13120 BRD-K89391146 THP1 80 uM 6 h 0.28 1.17 0.38 0.24 0.84 0.13
13386 BRD-K89391146 U937 80 uM 6 h -0.23 -0.97 0.1 -0.22 -0.75 0.06
13700 BRD-K89391146 VCAP 80 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.15
93619 BRD-K89391146 A549 10 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
93659 BRD-K89391146 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93721 BRD-K89391146 CD34 0.04 uM 24 h 0.32 1.32 0.8 0.2 0.71 0.02
93762 BRD-K89391146 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93847 BRD-K89391146 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93891 BRD-K89391146 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
93966 BRD-K89391146 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
94031 BRD-K89391146 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94110 BRD-K89391146 NEU 3.33 uM 24 h -0.24 -1.01 0.16 0.0 0.0 0.0
94141 BRD-K89391146 NPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94244 BRD-K89391146 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94296 BRD-K89391146 SKL 0.12 uM 24 h 0.0 0.0 0.0 0.39 1.39 2.17
94383 BRD-K89391146 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95626 BRD-K89391146 U2OS 0.5 uM 24 h 0.0 0.0 0.0 -0.49 -1.63 15.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).