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CMap Candidate Details

Structure:
CMap ID: C04598
Pert ID: BRD-K22024824
Compound Name: RG4733
Targets: PSEN1
MoA: gamma secretase inhibitor
SMILES: CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2ccccc2NC1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95851 BRD-K22024824 NPC 3.33 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95911 BRD-K22024824 YAPC 3.33 uM 6 h 0.0 0.0 0.0 0.26 0.91 0.23
118082 BRD-K22024824 A549 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
118168 BRD-K22024824 HCC515 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118217 BRD-K22024824 HEPG2 10 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
118264 BRD-K22024824 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118305 BRD-K22024824 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120862 BRD-K22024824 A375 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
120950 BRD-K22024824 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121073 BRD-K22024824 PC3 10 uM 24 h 0.23 0.94 0.06 0.22 0.8 0.08
129133 BRD-K22024824 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.17 -0.58 0.0
129151 BRD-K22024824 HELA 2.22 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).