CMap Candidate Details
Structure:
| CMap ID: | C00460 |
| Pert ID: | BRD-K24576554 |
| Compound Name: | AT-9283 |
| Targets: | AURKA|AURKB|JAK2|JAK3|RPS6KA6|STK17A |
| MoA: | Aurora kinase inhibitor; JAK inhibitor |
| SMILES: | O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 95490 | BRD-K24576554 | A549 | 1.11 uM | 24 h | 0.26 | 1.08 | 0.2 | -0.23 | -0.78 | 0.09 |
| 95632 | BRD-K24576554 | U2OS | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 119397 | BRD-K24576554 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 119494 | BRD-K24576554 | HCC515 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.25 | 0.9 | 0.21 |
| 119531 | BRD-K24576554 | HEPG2 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 121396 | BRD-K24576554 | HA1E | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.23 | 0.83 | 0.11 |
| 121430 | BRD-K24576554 | HELA | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.79 | 0.11 |
| 121455 | BRD-K24576554 | HT29 | 1.11 uM | 24 h | 0.27 | 1.15 | 0.32 | 0.0 | 0.0 | 0.0 |
| 121491 | BRD-K24576554 | PC3 | 0.04 uM | 24 h | -0.24 | -0.98 | 0.12 | 0.0 | 0.0 | 0.0 |
| 121547 | BRD-K24576554 | YAPC | 10 uM | 24 h | 0.23 | 0.98 | 0.09 | 0.0 | 0.0 | 0.0 |
| 129543 | BRD-K24576554 | MCF??7.00 | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.18 | -0.62 | 0.0 |