CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04613
Pert ID:	BRD-K30563334
Compound Name:	rifabutin
Targets:	HSP90AA1\|HSP90B1
MoA:	protein synthesis inhibitor
SMILES:	CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(c(O)c3C)c(O)c(NC(=O)\C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c1=NC3(CCN(CC(C)C)CC3)N=c21
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25351	BRD-K30563334	VCAP	10 uM	24 h	-0.3	-1.27	0.74	-0.33	-1.11	0.9
121916	BRD-K30563334	A549	10 uM	24 h	-0.19	-0.79	0.0	0.0	0.0	0.0
121957	BRD-K30563334	HEK293	0.125 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.12
121981	BRD-K30563334	HELA	0.37 uM	24 h	0.0	0.0	0.0	0.2	0.71	0.02
122010	BRD-K30563334	HT29	10 uM	24 h	0.0	0.0	0.0	0.21	0.76	0.05
122049	BRD-K30563334	HUVEC	1.11 uM	24 h	0.0	0.0	0.0	0.33	1.19	1.01
122107	BRD-K30563334	MCF??7.00	3.33 uM	24 h	0.27	1.13	0.29	0.0	0.0	0.0
122141	BRD-K30563334	MDAMB231	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122166	BRD-K30563334	PC3	1.11 uM	24 h	0.0	0.0	0.0	0.2	0.72	0.02
130185	BRD-K30563334	A375	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130228	BRD-K30563334	HA1E	0.08 uM	24 h	0.0	0.0	0.0	-0.23	-0.76	0.07
130350	BRD-K30563334	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130399	BRD-K30563334	MCF10A	0.74 uM	24 h	-0.3	-1.26	0.72	0.0	0.0	0.0
130495	BRD-K30563334	THP1	0.03 uM	24 h	-0.23	-0.94	0.08	0.22	0.8	0.08
130521	BRD-K30563334	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary