CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04614
Pert ID:	BRD-K01507359
Compound Name:	rifampin
Targets:	NR1I2\|SLCO1A2\|SLCO1B1\|SLCO1B3
MoA:	RNA polymerase inhibitor
SMILES:	CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(\C=N\N4CCN(C)CC4)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
33614	BRD-K01507359	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34025	BRD-K01507359	ASC	10 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.33
34808	BRD-K01507359	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.94	0.38
35077	BRD-K01507359	HT29	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.06	0.73
35530	BRD-K01507359	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36181	BRD-K01507359	PHH	10 uM	24 h	0.0	0.0	0.0	0.26	0.92	0.24
36475	BRD-K01507359	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36761	BRD-K01507359	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
49969	BRD-K01507359	A549	10 uM	6 h	0.28	1.15	0.34	0.0	0.0	0.0
50135	BRD-K01507359	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50324	BRD-K01507359	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.3	-1.0	0.52
50727	BRD-K01507359	MCF??7.00	10 uM	6 h	0.2	0.84	0.0	-0.26	-0.86	0.21
50898	BRD-K01507359	PC3	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
99211	BRD-K01507359	NPC	10 uM	6 h	0.0	0.0	0.0	0.27	0.97	0.35

Summary