CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04630
Pert ID:	BRD-K53814070
Compound Name:	ripasudil
Targets:	ROCK1\|ROCK2
MoA:	rho associated kinase inhibitor
SMILES:	C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
96872	BRD-K53814070	A375	10 uM	24 h	-0.23	-0.94	0.08	0.0	0.0	0.0
124300	BRD-K53814070	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.23	-0.79	0.1
124318	BRD-K53814070	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124419	BRD-K53814070	JURKAT	1.11 uM	24 h	-0.19	-0.79	0.0	0.0	0.0	0.0
124488	BRD-K53814070	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.18	0.62	0.0
124548	BRD-K53814070	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132359	BRD-K53814070	A549	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132444	BRD-K53814070	HELA	2.22 uM	24 h	0.19	0.78	0.0	0.27	0.97	0.34
132464	BRD-K53814070	HT29	0.08 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.42
132495	BRD-K53814070	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.68
132524	BRD-K53814070	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.35	1.25	1.29
132572	BRD-K53814070	PC3	2.22 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.3
132607	BRD-K53814070	THP1	0.25 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.28

Summary