CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04671
Pert ID:	BRD-K03194791
Compound Name:	roflumilast
Targets:	PDE4A\|PDE4B\|PDE4C\|PDE4D
MoA:	phosphodiesterase inhibitor
SMILES:	FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1422	BRD-K03194791	NPC	0.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
96714	BRD-K03194791	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122866	BRD-K03194791	HA1E	0.04 uM	24 h	0.2	0.84	0.0	-0.27	-0.92	0.33
122913	BRD-K03194791	HEK293	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122987	BRD-K03194791	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123038	BRD-K03194791	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123128	BRD-K03194791	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123154	BRD-K03194791	PC3	0.04 uM	24 h	0.29	1.2	0.43	0.0	0.0	0.0
123200	BRD-K03194791	THP1	0.04 uM	24 h	0.23	0.96	0.08	0.2	0.7	0.02
123221	BRD-K03194791	YAPC	10 uM	24 h	-0.22	-0.92	0.06	0.0	0.0	0.0
131256	BRD-K03194791	A549	0.03 uM	24 h	0.0	0.0	0.0	0.27	0.95	0.31
131314	BRD-K03194791	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.31	1.11	0.72
131375	BRD-K03194791	HUVEC	0.03 uM	24 h	0.26	1.07	0.2	0.28	0.99	0.39
131412	BRD-K03194791	MCF10A	2.22 uM	24 h	0.22	0.9	0.02	0.0	0.0	0.0
131447	BRD-K03194791	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary