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CMap Candidate Details

Structure:
CMap ID: C04683
Pert ID: BRD-K07691486
Compound Name: roscovitine
Targets: CDK2|CDK9
MoA: CDK inhibitor
SMILES: CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3330 BRD-K07691486 HCC515 10 uM 6 h 0.0 0.0 0.0 0.27 0.94 0.29
3722 BRD-K07691486 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42278 BRD-K07691486 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42614 BRD-K07691486 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42917 BRD-K07691486 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43154 BRD-K07691486 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
43777 BRD-K07691486 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91503 BRD-K07691486 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92071 BRD-K07691486 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92160 BRD-K07691486 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92314 BRD-K07691486 MDAMB231 0.04 uM 3 h 0.0 0.0 0.0 0.31 1.1 0.7
92391 BRD-K07691486 SKBR3 3.33 uM 3 h -0.27 -1.14 0.43 -0.2 -0.66 0.01
95429 BRD-K07691486 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95804 BRD-K07691486 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95904 BRD-K07691486 YAPC 10 uM 6 h 0.0 0.0 0.0 0.23 0.81 0.09
96722 BRD-K07691486 A375 10 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
122586 BRD-K07691486 A549 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.77
122664 BRD-K07691486 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122738 BRD-K07691486 MCF10A 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
130942 BRD-K07691486 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131060 BRD-K07691486 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131159 BRD-K07691486 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).