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CMap Candidate Details

Structure:
CMap ID: C04686
Pert ID: BRD-A97437073
Compound Name: rosiglitazone
Targets: ACSL4|FFAR1|PPARG|TRPC5|TRPM3
MoA: insulin sensitizer; PPAR receptor agonist
SMILES: CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3711 BRD-A97437073 VCAP 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
9079 BRD-A97437073 A549 80 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
9323 BRD-A97437073 AGS 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9626 BRD-A97437073 H1299 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9875 BRD-A97437073 HA1E 80 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
10250 BRD-A97437073 HCC515 80 uM 6 h 0.0 0.0 0.0 -0.25 -0.85 0.2
10427 BRD-A97437073 HCT116 80 uM 6 h -0.28 -1.16 0.46 -0.28 -0.93 0.36
10700 BRD-A97437073 HEPG2 80 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.9
11128 BRD-A97437073 MCF??7.00 80 uM 24 h -0.22 -0.9 0.05 -0.24 -0.8 0.12
11377 BRD-A97437073 NCIH2073 80 uM 6 h 0.34 1.41 1.03 0.0 0.0 0.0
11948 BRD-A97437073 NCIH596 80 uM 6 h 0.0 0.0 0.0 0.31 1.09 0.67
12231 BRD-A97437073 NOMO1 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12585 BRD-A97437073 PC3 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12696 BRD-A97437073 SW480 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13174 BRD-A97437073 U937 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44800 BRD-A97437073 ASC 10 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
46238 BRD-A97437073 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46551 BRD-A97437073 SKB 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
95693 BRD-A97437073 U2OS 1.11 uM 6 h 0.0 0.0 0.0 -0.39 -1.31 1.7
96448 BRD-A97437073 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
98987 BRD-A97437073 NEU 10 uM 6 h 0.23 0.95 0.06 0.0 0.0 0.0
99208 BRD-A97437073 NPC 10 uM 6 h -0.22 -0.9 0.04 0.0 0.0 0.0
128465 BRD-A97437073 HEK293 10 uM 24 h -0.15 -0.63 0.0 -0.25 -0.84 0.17
128489 BRD-A97437073 HELA 0.125 uM 24 h 0.3 1.23 0.5 0.0 0.0 0.0
128520 BRD-A97437073 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128575 BRD-A97437073 JURKAT 1.11 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
128606 BRD-A97437073 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128667 BRD-A97437073 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128746 BRD-A97437073 THP1 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
128785 BRD-A97437073 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).