CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04702
Pert ID:	BRD-K87048468
Compound Name:	RS-102221
Targets:	HTR2A\|HTR2B\|HTR2C
MoA:	serotonin receptor antagonist
SMILES:	COc1cc(OC)c(cc1NS(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2934	BRD-K87048468	HA1E	10 uM	24 h	0.27	1.14	0.32	0.0	0.0	0.0
3278	BRD-K87048468	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3557	BRD-K87048468	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3884	BRD-K87048468	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39208	BRD-K87048468	A375	10 uM	6 h	0.0	0.0	0.0	0.33	1.17	0.92
39357	BRD-K87048468	A549	10 uM	24 h	-0.26	-1.1	0.35	-0.36	-1.21	1.24
39802	BRD-K87048468	ASC	10 uM	24 h	0.3	1.25	0.54	0.0	0.0	0.0
40094	BRD-K87048468	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
40359	BRD-K87048468	HT29	10 uM	6 h	-0.19	-0.78	0.0	0.24	0.85	0.14
40522	BRD-K87048468	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40902	BRD-K87048468	NEU	10 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.37
41223	BRD-K87048468	NPC	10 uM	24 h	-0.26	-1.08	0.3	0.0	0.0	0.0
41562	BRD-K87048468	SKB	10 uM	24 h	-0.26	-1.07	0.28	0.19	0.69	0.01

Summary