CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04704
Pert ID:	BRD-K90825648
Compound Name:	RS-127445
Targets:	HTR2A\|HTR2B\|HTR2C
MoA:	serotonin receptor antagonist
SMILES:	CC(C)c1cc(nc(N)n1)-c1ccc(F)c2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
128150	BRD-K90825648	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128240	BRD-K90825648	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128319	BRD-K90825648	MDAMB231	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128340	BRD-K90825648	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128362	BRD-K90825648	THP1	3.33 uM	24 h	0.0	0.0	0.0	-0.23	-0.77	0.08
135762	BRD-K90825648	A375	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135824	BRD-K90825648	HA1E	0.01 uM	24 h	0.0	0.0	0.0	-0.22	-0.73	0.04
135863	BRD-K90825648	HEK293	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135914	BRD-K90825648	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.29	1.01	0.44
135954	BRD-K90825648	HT29	0.03 uM	24 h	0.27	1.14	0.32	-0.26	-0.89	0.26
136004	BRD-K90825648	JURKAT	0.03 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.27
136035	BRD-K90825648	MCF??7.00	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
136150	BRD-K90825648	YAPC	0.03 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.45

Summary