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CMap Candidate Details

Structure:
CMap ID: C04723
Pert ID: BRD-K88560311
Compound Name: rucaparib
Targets: PARP1|PARP2
MoA: PARP inhibitor
SMILES: CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1181 BRD-K88560311 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1256 BRD-K88560311 A549 10 uM 48 h 0.19 0.79 0.0 0.0 0.0 0.0
1295 BRD-K88560311 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1401 BRD-K88560311 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9024 BRD-K88560311 A375 10 uM 6 h 0.2 0.84 0.0 0.0 0.0 0.0
9535 BRD-K88560311 AGS 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.89 0.27
9841 BRD-K88560311 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10092 BRD-K88560311 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10261 BRD-K88560311 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10618 BRD-K88560311 HCT116 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
10868 BRD-K88560311 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11031 BRD-K88560311 HT29 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
11602 BRD-K88560311 NCIH2073 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.12
11861 BRD-K88560311 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12891 BRD-K88560311 SW480 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.91
13384 BRD-K88560311 U937 10 uM 6 h 0.2 0.81 0.0 0.26 0.91 0.24
13698 BRD-K88560311 VCAP 10 uM 6 h 0.2 0.85 0.01 0.41 1.45 2.22
93661 BRD-K88560311 ASC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93724 BRD-K88560311 CD34 0.04 uM 24 h 0.29 1.2 0.43 0.21 0.73 0.03
93850 BRD-K88560311 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93894 BRD-K88560311 HELA 0.04 uM 24 h -0.2 -0.82 0.0 0.38 1.35 1.72
93967 BRD-K88560311 HUVEC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94034 BRD-K88560311 JURKAT 10 uM 24 h -0.18 -0.74 0.0 -0.31 -1.06 0.72
94114 BRD-K88560311 NEU 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94159 BRD-K88560311 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94248 BRD-K88560311 SHSY5Y 0.12 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
94299 BRD-K88560311 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94344 BRD-K88560311 THP1 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
94386 BRD-K88560311 YAPC 1.11 uM 24 h 0.21 0.87 0.01 0.29 1.03 0.52
96011 BRD-K88560311 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).