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CMap Candidate Details

Structure:
CMap ID: C04740
Pert ID: BRD-K20285085
Compound Name: R406
Targets: RET|SYK
MoA: SYK inhibitor
SMILES: COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
477 BRD-K20285085 BJAB 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
523 BRD-K20285085 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
587 BRD-K20285085 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
615 BRD-K20285085 KMS34 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
660 BRD-K20285085 MINO 2.5 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
707 BRD-K20285085 NALM6 10 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.01
751 BRD-K20285085 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
801 BRD-K20285085 OCILY3 10 uM 24 h 0.29 1.23 0.5 -0.27 -0.92 0.34
848 BRD-K20285085 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
896 BRD-K20285085 THP1 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
952 BRD-K20285085 TMD8 10 uM 4 h 0.0 0.0 0.0 -0.29 -0.97 0.44
1233 BRD-K20285085 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1333 BRD-K20285085 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
9383 BRD-K20285085 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9695 BRD-K20285085 H1299 10 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.28
10366 BRD-K20285085 HCC515 10 uM 6 h 0.0 0.0 0.0 0.4 1.41 2.19
10756 BRD-K20285085 HEPG2 10 uM 6 h 0.24 1.02 0.13 -0.25 -0.83 0.16
11444 BRD-K20285085 NCIH2073 10 uM 6 h -0.21 -0.86 0.02 0.38 1.35 1.72
11733 BRD-K20285085 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12285 BRD-K20285085 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12756 BRD-K20285085 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13236 BRD-K20285085 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13598 BRD-K20285085 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90625 BRD-K20285085 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91644 BRD-K20285085 MCF??7.00 10 uM 24 h 0.21 0.89 0.02 -0.38 -1.28 1.45
91769 BRD-K20285085 SKBR3 10 uM 6 h -0.18 -0.74 0.0 0.23 0.83 0.11
92402 BRD-K20285085 A375 1.11 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
92454 BRD-K20285085 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92556 BRD-K20285085 HME1 3.33 uM 3 h 0.0 0.0 0.0 -0.26 -0.86 0.21
92602 BRD-K20285085 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92653 BRD-K20285085 LNCAP 10 uM 24 h 0.32 1.35 0.93 0.0 0.0 0.0
92709 BRD-K20285085 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
92785 BRD-K20285085 MDAMB231 10 uM 3 h 0.24 1.0 0.11 0.44 1.55 2.32
98058 BRD-K20285085 P1A82 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
120938 BRD-K20285085 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120984 BRD-K20285085 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121011 BRD-K20285085 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121069 BRD-K20285085 PC3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
121096 BRD-K20285085 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
129129 BRD-K20285085 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).