CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C04741
Pert ID:	BRD-K52233191
Compound Name:	R547
Targets:	CDK1\|CDK2\|CDK4\|CDK7
MoA:	CDK inhibitor
SMILES:	COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1300	BRD-K52233191	MCF??7.00	1.11 uM	6 h	0.0	0.0	0.0	0.3	1.05	0.57
1314	BRD-K52233191	U2OS	1.11 uM	24 h	-0.26	-1.1	0.34	0.0	0.0	0.0
90840	BRD-K52233191	MCF10A	1.11 uM	24 h	-0.27	-1.14	0.42	0.26	0.93	0.27
97266	BRD-K52233191	HAP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
97341	BRD-K52233191	A375	0.66 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124380	BRD-K52233191	HT29	0.37 uM	24 h	0.16	0.68	0.0	-0.31	-1.05	0.7
124406	BRD-K52233191	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.14
124483	BRD-K52233191	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124511	BRD-K52233191	PC3	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124538	BRD-K52233191	YAPC	0.37 uM	24 h	0.0	0.0	0.0	0.39	1.37	1.97
132352	BRD-K52233191	A549	0.25 uM	24 h	-0.24	-0.98	0.12	0.0	0.0	0.0
132382	BRD-K52233191	HA1E	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132414	BRD-K52233191	HEK293	2.22 uM	24 h	-0.22	-0.93	0.07	-0.38	-1.28	1.45
132439	BRD-K52233191	HELA	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132594	BRD-K52233191	THP1	0.74 uM	24 h	-0.27	-1.14	0.42	-0.24	-0.8	0.12

Summary